Creatine for Brain Energy: Can It Help During Mental Fatigue? Your brain needs energy to perform at its best. Research suggests that creatine may help support ATP production—the brain's primary energy source—during periods of sleep deprivation and intense mental effort. While it's not a replacement for quality sleep, creatine monohydrate may help support focus, attention, and cognitive performance when your brain is under increased demand. To know more about creatine and sleep deprivation visit on: https://projectcreatine.com/how-creatine-helps-the-brain-during-sleep-deprivation-mental-fatigue-and-stress/