Taming the "Trojan Horse": Preclinical Safety Strategies...

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2026-07-15 06:41:13 -

Taming the "Trojan Horse": Preclinical Safety Strategies and Off-Target Risk Mitigation for Solid Tumor ADCs

Antibody-Drug Conjugates (ADCs) have revolutionized oncology, earning their reputation as biological "Trojan horses." By tethering a highly potent cytotoxic payload to a target-specific monoclonal antibody, ADCs promise to deliver chemotherapy directly to malignant cells while sparing healthy tissues. However, translating this elegant concept into a safe, clinically viable therapeutic is...

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